Crisaborole Impurity 1 (INR 29900/- 50 mg, in stock)
Catalogue No:
ACT-C019001
Common name:
Crisaborole Impurity 1
CAS:
2803552-55-6
Mol. Weight:
241.3
Rel. CAS No
- NA
Shipping Condition
Ambient
Product Overview
Chemical Name:
4-(4-Hydroxy-3-(hydroxymethyl)phenoxy)benzonitrile
Shipping Temperature:
Ambient
HSN Code:
38229010
Country of Origin:
India
Smiles:
OC1=CC=C(OC2=CC=C(C#N)C=C2)C=C1CO
Description
Crisaborole Impurity 1 (CAS 2803552-55-6) is a pharmaceutical impurity reference standard related to crisaborole, molecular formula C14H11NO3, molecular weight 241.25. It is the des-boron analogue of the parent, also indexed by suppliers as Crisaborole Hydroxy Impurity. Crisaborole is a topical benzoxaborole PDE4 inhibitor used in atopic dermatitis. Allas Chem Tech is a manufacturer and supplier of pharmaceutical reference standards based in Bangalore, India, and holds this crisaborole impurity in stock in 50 mg packs at Rs.29900/-, supplied with a certificate of analysis and complete characterisation data.
Specifications
| Field | Value |
|---|---|
| Catalogue No. | ACT-C019001 |
| CAS No. | 2803552-55-6 |
| Chemical Name | 4-(4-Hydroxy-3-(hydroxymethyl)phenoxy)benzonitrile |
| Mol. Formula | C14H11NO3 |
| Mol. Weight | 241.25 g/mol |
| Parent API | Crisaborole |
| Product Category | Impurity Reference Standard |
| Pack Size | 50 mg |
| Price | Rs.29900/- per 50 mg |
| Stock Status | In Stock |
| SMILES | OC1=CC=C(OC2=CC=C(C#N)C=C2)C=C1CO |
| Shipping | Ambient |
| HSN Code | 38229010 |
| Country of Origin | India |
Analytical applications
Crisaborole Impurity 1 is used in analytical method development and method validation (AMV), and in Quality Control (QC) applications supporting Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA) and commercial production of crisaborole.
Process-related impurity control
The molecular formula C14H11NO3 contains no boron, whereas crisaborole itself is a benzoxaborole carrying boron in the ring. This impurity therefore represents material in which the benzoxaborole ring has not closed, making it a process-related marker for the cyclisation step rather than a degradation product.
Stability and release testing
Crisaborole is known to be sensitive to aqueous conditions, which makes impurity profiling of both drug substance and topical formulation a routine requirement. A characterised standard is needed to identify and quantify this impurity in stability-indicating methods and in QC release testing.
Documentation supplied
Every order of Crisaborole Impurity 1 ships with a Certificate of Analysis (COA), 1H NMR, 13C NMR, Mass/LC-MS, HPLC, FT-IR and TGA potency data. An MSDS, 2D NMR (COSY, HSQC, HMBC) and a Structure Elucidation Report are available on request.
Synonyms and alternate designations
Suppliers index this compound under several names. All of the following describe the same material, CAS 2803552-55-6.
Crisaborole Hydroxy Impurity
Crisaborole Impurity 10 (used by some suppliers for this CAS)
5-(4-Cyanophenoxy)-2-hydroxy benzyl alcohol
4-(4-Hydroxy-3-(hydroxymethyl)phenoxy)benzonitrile
Frequently asked questions
What is the CAS number of Crisaborole Impurity 1?
The CAS number is 2803552-55-6.
Which drug is this an impurity of?
Crisaborole, a topical benzoxaborole PDE4 inhibitor used in the treatment of atopic dermatitis.
Why does this impurity contain no boron?
Crisaborole is a benzoxaborole and carries boron in its ring system. This impurity has the formula C14H11NO3, with no boron, and therefore represents material in which the ring has not closed during synthesis.
What is the molecular formula and weight?
The molecular formula is C14H11NO3 and the molecular weight is 241.25 g/mol.
Where can I buy Crisaborole Impurity 1?
Allas Chem Tech supplies it directly from our Bangalore facility. It is in stock in 50 mg packs at Rs.29900/-, shipped at ambient temperature.
What documentation is included?
COA, MSDS, NMR, Mass, HPLC, IR and TGA potency data, with a Structure Elucidation Report available on request.
