D-(His)-1-Semaglutide (INR 99000/- 50 mg, 5-6 weeks)

Catalogue No:

ACT-S007001

Common name:

H-D-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-SerTyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys (AEEAc-AEEAc-gamma-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-ValArg-Gly-Arg-Gly-OH

CAS:

Mol. Weight:

4113.60

Rel. CAS No

Shipping Condition

cold shipment

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Product Overview

Chemical Name:

(3S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,45S,48S,51S,54S,81S)-54-(((6S,12S,15S,18S,21S,24S,27S,30S,33S)-21-((1H-Indol-3-yl)methyl)-1-amino-30-benzyl-27-((S)-sec-butyl)-35-carboxy-6-((carboxymethyl)carbamoyl)-12-(3-guanidinopropyl)-1-imino-18-isobutyl-15-isopropyl-24-methyl-8,11,14,17,20,23,26,29,32-nonaoxo-2,7,10,13,16,19,22,25,28,31-decaazapentatriacontan-33-yl)carbamoyl)-3-(2-((R)-2-amino-3-(1H-imidazol-4-yl)propanamido)-2-methylpropanamido)-45-(3-amino-3-oxopropyl)-12-benzyl-39-(2-carboxyethyl)-21-(carboxymethyl)-33-(4-hydroxybenzyl)-9,15-bis((R)-1-hydroxyethyl)-18,27,30-tris(hydroxymethyl)-36-isobutyl-24-isopropyl-48,51-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,60,69,78,83-henicosaoxo-62,65,71,74-tetraoxa-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,59,68,77,82-henicosaazanonanonacontane-1,81,99-tricarboxylic acid

Shipping Temperature:

cold shipment

HSN Code:

38229010

Country of Origin:

India

Smiles:

CC(C)[C@@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@@H](C)O)NC(CNC([C@H](CCC(O)=O)NC(C(C)(C)NC([C@H](N)CC5=CNC=N5)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O

Description

D-His-1-Semaglutide is a pharmaceutical impurity reference standard related to Semaglutide, molecular formula C187H291N45O59 (expected by analogy to sibling rows; not independently sourced for this specific compound -- see Open Items), molecular weight 4113.64 (expected by analogy; see Open Items). Identified industry-wide by amino-acid sequence rather than by a CAS number (sequence not published -- no direct source found). Allas Chem Tech, a Bangalore-based manufacturer and supplier of pharmaceutical reference standards, carries this material in 50 mg packs at Rs.99000/-, supplied with a certificate of analysis and complete characterisation data.

Specifications

Field	Value
Catalogue No.	Pending (client SKU — not available without live-site access)
CAS No.	Not assigned (see Open Items)
Amino Acid Sequence	Not published -- no direct source found
Chemical Name	Identified industry-wide by amino-acid sequence rather than by a CAS number (sequence not published -- no direct source found).
Mol. Formula	C187H291N45O59 (expected by analogy; see Open Items)
Mol. Weight	4113.64 (expected by analogy; see Open Items)
Parent API	Semaglutide
Product Category	Impurity Reference Standard
Pack Size	50 mg
Price	Rs.99000/- per 50 mg
Stock Status	Ships in 5-6 Weeks
SMILES	Not published by third-party sources consulted
Shipping	Ambient
HSN Code	38229010
Country of Origin	India

Analytical applications

D-His-1-Semaglutide is used in analytical method development and method validation (AMV), and in Quality Control (QC) applications supporting Abbreviated New Drug Applications (ANDA) and commercial production of semaglutide.

STRONG FLAG: zero third-party corroboration found; closes 11-row Semaglutide peptide run

STRONG FLAG: zero third-party corroboration found for a "D-His-1-Semaglutide" impurity under this exact name across targeted searches of Daicel, SynZeal, Clearsynth, KM Pharma and Pharmaffiliates. By analogy to the other single-point D-isomer impurities in this run (rows 249, 250, 253), a D-His-1 impurity of Semaglutide would be expected to share Semaglutide's own formula/MW (C187H291N45O59, 4113.64) -- shown above as an analogy-based estimate, NOT a sourced fact. Closes out the 11-row Semaglutide peptide-impurity run (rows 244-254). Recommend priority chemist review before this page goes live.

Quality control and regulatory filings

The standard supports routine QC release testing of semaglutide drug substance and drug product, and is used to generate impurity data submitted in ANDA and DMF applications. Full characterisation data accompanies every batch for direct citation in regulatory documentation.

Documentation supplied

Every order of D-His-1-Semaglutide ships with a Certificate of Analysis (COA), 1H NMR, 13C NMR, Mass/LC-MS, HPLC, FT-IR and TGA potency data. An MSDS, a Structure Elucidation Report and 2D NMR (COSY, HSQC, HMBC) are available on request.

Synonyms and alternate designations

Full chemical/IUPAC name: Identified industry-wide by amino-acid sequence rather than by a CAS number (sequence not published -- no direct source found). No confirmed synonym could be located for this exact impurity -- see the STRONG FLAG above and Open Items.

Frequently asked questions

What is the CAS number of D-His-1-Semaglutide?

D-His-1-Semaglutide does not currently have an assigned CAS Registry Number; it is identified industry-wide by amino-acid sequence rather than CAS number.

Which drug is this an impurity of?

It is a Semaglutide impurity.

What is the molecular formula and weight?

The molecular formula is C187H291N45O59 and the molecular weight is 4113.64, both expected by analogy to sibling D-isomer rows (see Open Items for sourcing caveat).

Where can I buy D-His-1-Semaglutide?

Allas Chem Tech supplies it directly from our Bangalore facility. D-His-1-Semaglutide is listed at Rs.99000/- per 50 mg for a 50 mg pack; current availability per the product URL slug is ships in 5-6 weeks.

What documentation is included?

COA, MSDS, NMR, Mass, HPLC, IR and TGA potency data, with a Structure Elucidation Report available on request.