Ezetimibe Benzyl Ether Impurity (INR 5900/- 50 mg, in stock)
Catalogue No:
ACT-E005002
Common name:
Ezetimibe Benzyl Ether
CAS:
163222-32-0
Mol. Weight:
499.6
Rel. CAS No
- NA
Shipping Condition
Ambient
Product Overview
Chemical Name:
(3R,4S)-4-(4-(Benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one
Shipping Temperature:
Ambient
HSN Code:
38229010
Country of Origin:
India
Smiles:
O[C@H](C1=CC=C(F)C=C1)CC[C@@H]2[C@@H](C3=CC=C(OCC4=CC=CC=C4)C=C3)N(C5=CC=C(F)C=C5)C2=O
Description
Ezetimibe Benzyl Ether Impurity (CAS 163222-32-0) is a pharmaceutical impurity reference standard supplied by Allas Chem Tech, related to Ezetimibe. It is intended for use in analytical method validation (AMV) and routine quality control (QC) testing of Ezetimibe drug substance and drug product batches.
About This Impurity Standard
Ezetimibe Benzyl Ether Impurity is characterised and supplied as a 50 mg reference standard pack, priced at Rs.5900/- and currently shown as In Stock on the product listing. CAS confirmed by 3 independent sources (Veeprho, Clearsynth, BOC Sciences). Closes the 4-row Ezetimibe family for this batch. This is the benzyl-protected-phenol synthetic intermediate — Ezetimibe's own 4'-phenolic hydroxyl is capped as an O-benzyl ether, the exact protecting-group intermediate carried through the synthetic route before hydrogenolytic debenzylation reveals the free phenol of finished Ezetimibe. MW (499.50) is 90.10 higher than parent Ezetimibe (409.40), matching replacement of the phenolic hydrogen with a benzyl group (+C7H6). This CAS number (163222-32-0) is also numerically adjacent to parent Ezetimibe's own CAS (163222-33-1), consistent with sequential registration of a family of related synthetic intermediates. Rows 375-378 form a mechanistically coherent, mutually consistent set of four distinct Ezetimibe process compounds — a ring-isomer (375, same MW as parent), a keto-oxidation product (376, -2 amu), a bis-acetate intermediate (377, +84 amu), and this benzyl-ether intermediate (378, +90 amu).
Specifications
| Specification | Detail |
| Catalogue No. | Pending (client SKU — not available without live-site access) |
| CAS Number | 163222-32-0 |
| Chemical Name | (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-phenylmethoxyphenyl)azetidin-2-one |
| Molecular Formula | C31H27F2NO3 |
| Molecular Weight | 499.50 |
| Parent API | Ezetimibe |
| Category | Pharmaceutical Impurity Reference Standard |
| Pack Size | 50 mg |
| Price | Rs.5900/- (50 mg) |
| Stock Status | In Stock |
| SMILES | C1=CC=C(C=C1)COC2=CC=C(C=C2)C3C(C(=O)N3C4=CC=C(C=C4)F)CCC(C5=CC=C(C=C5)F)O |
| Shipping | Dispatched per the lead time shown in Stock Status above |
| HSN Code | 38229010 |
| Country of Origin | India |
Analytical Applications
General Use
This reference standard supports impurity profiling, forced-degradation studies, and stability-indicating HPLC/UPLC method development and validation for Ezetimibe-based formulations, in line with ICH Q3A/Q3B impurity qualification requirements.
Compound-Specific Notes
No conflicts across 3 sources. Confirmed as the benzyl-protected-phenol synthetic intermediate of Ezetimibe ("4'-O-Benzyl Ezetimibe"), CAS numerically adjacent to parent Ezetimibe's own CAS. Closes a mechanistically coherent 4-row Ezetimibe family (375-378) spanning a ring-isomer, a keto-oxidation product, a diacetate, and this benzyl ether.
Quality Control
Use of a well-characterized Ezetimibe Benzyl Ether Impurity reference standard supports accurate peak identification and quantitation during routine QC release testing and stability studies for Ezetimibe drug substance and finished-dose batches.
Documentation Supplied
Each unit of Ezetimibe Benzyl Ether Impurity ships with a Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and supporting HPLC chromatographic/analytical data confirming the stated identity and purity.
Synonyms and Alternate Designations
- 4'-O-Benzyl Ezetimibe (confirmed alternate name for the same CAS, stated by the sourced material)
- Ezetimibe Impurity 41 (confirmed alternate catalog name for the same CAS, stated by the sourced material)
Frequently Asked Questions
What is Ezetimibe Benzyl Ether Impurity used for?
Ezetimibe Benzyl Ether Impurity is used as a pharmaceutical impurity reference standard for analytical method validation (AMV) and routine quality control testing of Ezetimibe and its formulations.
Is Ezetimibe Benzyl Ether Impurity available in stock?
Ezetimibe Benzyl Ether Impurity is listed at Rs.5900/- (50 mg) for a 50 mg pack; current availability is shown as in stock on the Allas Chem Tech product page.
Does Ezetimibe Benzyl Ether Impurity have a CAS number?
The CAS Registry Number for Ezetimibe Benzyl Ether Impurity is 163222-32-0.
What documentation is supplied with Ezetimibe Benzyl Ether Impurity?
Each unit of Ezetimibe Benzyl Ether Impurity ships with a Certificate of Analysis (CoA), Material Safety Data Sheet (MSDS), and supporting HPLC analytical data.
