Macitentan Sulfamide Dimer (INR 19900/- 50 mg, in stock)
Catalogue No:
ACT-M016005
Common name:
Macitentan Pyrimidine Dimer
CAS:
2089065-77-8
Mol. Weight:
800.5
Rel. CAS No
- NA
Shipping Condition
Ambient
Product Overview
Chemical Name:
(N,N′′-[1,2-Ethanediylbis[oxy[5-(4-bromophenyl)-6,4-pyrimidinediyl]]]bis[N′-propylsulfamide]) (as per USP)
Shipping Temperature:
Ambient
HSN Code:
38229010
Country of Origin:
India
Smiles:
O=[S](NC1=NC=NC(OCCOC2=NC=NC(N[S](NCCC)(=O)=O)=C2C3=CC=C(Br)C=C3)=C1C4=CC=C(Br)C=C4)(NCCC)=O
Description
Macitentan Sulfamide Dimer (CAS 2089065-77-8) is a pharmaceutical impurity reference standard related to macitentan, molecular formula C28H32Br2N8O6S2, molecular weight 800.5, also indexed as the Macitentan Pyrimidine Dimer. It forms when two macitentan-related pyrimidine sulfamide units join through a shared ethylenedioxy bridge. Allas Chem Tech is a manufacturer and supplier of pharmaceutical reference standards based in Bangalore, India, and holds this macitentan impurity in stock in 50 mg packs at Rs.19900/-, supplied with a certificate of analysis and complete characterisation data.
Specifications
|
Field |
Value |
|---|---|
| Catalogue No. | ACT-M016005 |
| CAS No. | 2089065-77-8 |
| Chemical Name | N,N''-[1,2-Ethanediylbis[oxy[5-(4-bromophenyl)-6,4-pyrimidinediyl]]]bis[N'-propylsulfamide] |
| Mol. Formula | C28H32Br2N8O6S2 (computed from the SMILES on the live Allas page) |
| Mol. Weight | 800.5 g/mol |
| Parent API | Macitentan |
| Product Category | Impurity Reference Standard |
| Pack Size | 50 mg |
| Price | Rs.19900/- per 50 mg |
| Stock Status | In Stock |
| SMILES | O=[S](NC1=NC=NC(OCCOC2=NC=NC(N[S](NCCC)(=O)=O)=C2C3=CC=C(Br)C=C3)=C1C4=CC=C(Br)C=C4)(NCCC)=O |
| Shipping | Ambient |
| HSN Code | 38229010 |
| Country of Origin | India |
Analytical applications
Macitentan Sulfamide Dimer is used in analytical method development and method validation (AMV), and in Quality Control (QC) applications supporting ANDA and commercial production of macitentan.
Dimer impurity control
Dimeric impurities of this kind typically arise from incomplete separation during the etherification step that links two pyrimidine-sulfamide units. It is related on the same synthetic route to Macitentan Pyrimidine Amine Impurity (row 8) and O-Desbromo-Pyrimidinyl Macitentan (row 12), also stocked by Allas.
Quality control and regulatory filings
The standard supports routine QC release testing of macitentan drug substance and drug product, and is used to generate impurity data submitted in ANDA and DMF applications. Full characterisation data accompanies every batch.
Documentation supplied
Every order of Macitentan Sulfamide Dimer ships with a Certificate of Analysis (COA), 1H NMR, 13C NMR, Mass/LC-MS, HPLC, FT-IR and TGA potency data. An MSDS and a Structure Elucidation Report are available on request.
Synonyms and alternate designations
All of the following describe the same material, CAS 2089065-77-8.
Macitentan Pyrimidine Dimer
N,N''-[1,2-Ethanediylbis[oxy[5-(4-bromophenyl)-6,4-pyrimidinediyl]]]bis[N'-propylsulfamide]
Related Allas standards on the same synthetic route: Macitentan Pyrimidine Amine Impurity (row 8) and O-Desbromo-Pyrimidinyl Macitentan (row 12). Cross-link all three once live.
Frequently Asked Questions
What is the CAS number of Macitentan Sulfamide Dimer?
The CAS number is 2089065-77-8.
Which drug is this an impurity of?
It is a Macitentan impurity. Macitentan is a dual endothelin receptor antagonist used to treat pulmonary arterial hypertension.
Why is it called a dimer?
Because it consists of two macitentan-related pyrimidine sulfamide units joined by a shared ethylenedioxy bridge, rather than a single monomer.
What is the molecular formula and weight?
The molecular formula is C28H32Br2N8O6S2 and the molecular weight is 800.5 g/mol.
Where can I buy Macitentan Sulfamide Dimer?
Allas Chem Tech supplies it directly from our Bangalore facility. It is in stock in 50 mg packs at Rs.19900/-, shipped at ambient temperature.
What documentation is included?
COA, MSDS, NMR, Mass, HPLC, IR and TGA potency data, with a Structure Elucidation Report available on request.
