Tolvaptan Impurity 10 (INR 15900/- 50 mg, in stock)
Catalogue No:
ACT-T014004
Common name:
1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
CAS:
137977-97-0
Mol. Weight:
328.8
Rel. CAS No
- NA
Shipping Condition
Ambient
Product Overview
Chemical Name:
1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
Shipping Temperature:
Ambient
HSN Code:
38229010
Country of Origin:
India
Smiles:
O=C(C(C=CC(N)=C1)=C1C)N(CCC2)C3=CC=C(Cl)C=C3C2=O
Description
Tolvaptan Impurity 10 (CAS 137977-97-0) is a pharmaceutical impurity reference standard related to tolvaptan, molecular formula C18H17ClN2O2, molecular weight 328.8. Chemically 1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one, it retains one of tolvaptan's two amino-methylbenzoyl-type groups while lacking the second benzamide substituent present in the finished API, placing it as a mono-acylated synthetic intermediate. Allas Chem Tech, a Bangalore-based manufacturer and supplier of pharmaceutical reference standards, holds this material in stock in 50 mg packs at Rs.15,900/-, supplied with a certificate of analysis and complete characterisation data.
Specifications
| Field |
Value |
|---|---|
| Catalogue No. | ACT-T014004 |
| CAS No. | 137977-97-0 |
| Chemical Name | 1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one |
| Mol. Formula | C18H17ClN2O2 (computed from the SMILES on the live Allas page; matches the page's own displayed 328.8 exactly) |
| Mol. Weight | 328.8 g/mol |
| Parent API | Tolvaptan |
| Product Category | Impurity Reference Standard |
| Pack Size | 50 mg |
| Price | Rs.15,900/- per 50 mg |
| Stock Status | In Stock |
| SMILES | O=C(C(C=CC(N)=C1)=C1C)N(CCC2)C3=CC=C(Cl)C=C3C2=O |
| Shipping | Ambient |
| HSN Code | 38229010 |
| Country of Origin | India |
Analytical applications
Tolvaptan Impurity 10 is used in analytical method development and method validation (AMV), and in Quality Control (QC) applications supporting Abbreviated New Drug Applications (ANDA) and commercial production of tolvaptan.
Mono-acylated intermediate process control
Retaining only one of tolvaptan's two acylated substituents, this impurity indicates incomplete di-acylation during synthesis, making it a process-related synthetic intermediate rather than a storage degradant.
Quality control and regulatory filings
The standard supports routine QC release testing of tolvaptan drug substance and formulated tablets, and is used to generate impurity data submitted in ANDA and DMF applications. Full characterisation data accompanies every batch for direct citation in regulatory documentation.
Documentation supplied
Every order of Tolvaptan Impurity 10 ships with a Certificate of Analysis (COA), 1H NMR, 13C NMR, Mass/LC-MS, HPLC, FT-IR and TGA potency data. An MSDS, a Structure Elucidation Report and 2D NMR (COSY, HSQC, HMBC) are available on request.
Synonyms and alternate designations
All of the following describe the same material, CAS 137977-97-0.
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
Frequently asked questions
What is the CAS number of Tolvaptan Impurity 10?
The CAS number is 137977-97-0.
Which drug is this an impurity of?
It is a Tolvaptan impurity. Tolvaptan is a vasopressin receptor antagonist used to treat hyponatremia and polycystic kidney disease.
What is the molecular formula and weight?
The molecular formula is C18H17ClN2O2 and the molecular weight is 328.8 g/mol.
Where can I buy Tolvaptan Impurity 10?
Allas Chem Tech supplies it directly from our Bangalore facility. It is in stock in 50 mg packs at Rs.15,900/-, shipped at ambient temperature.
What documentation is included?
COA, MSDS, NMR, Mass, HPLC, IR and TGA potency data, with a Structure Elucidation Report available on request.
